EFFECTS OF RAT GALANIN AND GALANIN MESSAGE ASSOCIATED PEPTIDE (GMAP) ON RAT GROWTH-HORMONE SECRETION AND STIMULATING EFFECT OF GAMMA-AMINOBUTYRIC-ACID ON GALANIN RELEASE FROM RAT HYPOTHALAMUS

Authors
NISHIKI M MURAKAMI Y SOHMIYA M TANAKA J YAMAUCHI K KOSHIMURA K KATO Y
Citation
M. Nishiki et al., EFFECTS OF RAT GALANIN AND GALANIN MESSAGE ASSOCIATED PEPTIDE (GMAP) ON RAT GROWTH-HORMONE SECRETION AND STIMULATING EFFECT OF GAMMA-AMINOBUTYRIC-ACID ON GALANIN RELEASE FROM RAT HYPOTHALAMUS, Neuroscience letters, 226(3), 1997, pp. 199-202
Citations number
14
Categorie Soggetti
Neurosciences
Journal title
Neuroscience letters → ACNP
ISSN journal
03043940
Volume
226
Issue
3
Year of publication
1997
Pages
199 - 202
Database
ISI
SICI code
0304-3940(1997)226:3<199:EORGAG>2.0.ZU;2-3
Abstract
Immunoreactive galanin and galanin message associated peptide (GMAP) w ere detectable in rat hypothalamus in the concentration of 563 +/- 23 and 14.3 +/- 3.1 fmol/hypothalamus, respectively, gamma-Aminobutyric a cid (GABA) elicited a dose-related increase in galanin release from ra t hypothalamic fragments, which was inhibited by picrotoxin, a GABA an tagonist. Growth hormone (GH) secretion from rat anterior pituitary ce lls were stimulated by rat galanin, but not by GMAP. These findings su ggest that hypothalamic galanin, but not GMAP, may play roles in GH se cretion induced by GABAergic mechanisms in the rat. (C) 1997 Elsevier Science Ireland Ltd.