READING WITHIN THE LINES - NATURALLY PROCESSED PEPTIDES DISPLAYED BY MHC CLASS-I MOLECULES

Authors
SHASTRI N SERWOLD T PAZ P
Citation
N. Shastri et al., READING WITHIN THE LINES - NATURALLY PROCESSED PEPTIDES DISPLAYED BY MHC CLASS-I MOLECULES, Current opinion in immunology, 10(2), 1998, pp. 137-144
Citations number
77
Categorie Soggetti
Immunology
Journal title
Current opinion in immunology → ACNP
ISSN journal
09527915
Volume
10
Issue
2
Year of publication
1998
Pages
137 - 144
Database
ISI
SICI code
0952-7915(1998)10:2<137:RWTL-N>2.0.ZU;2-U
Abstract
A typical mammalian cell contains tens of thousands of different gene products. Snippets of this genetic information are displayed on the ce ll surface by MHC class I molecules as short peptides for immune surve illance by CD8(+) T lymphocytes. Genetic and biochemical analysis of t hese peptides is revealing novel sources and mechanisms by which these peptide/MHC class I complexes arise. (C) Current Biology Ltd ISSN 095 2-7915.