TRANSCRIPTIONAL CONTROL DURING T-CELL DEVELOPMENT

During the past few years, the essential role of distinct transcriptio n factors in specifying cell-fate decisions in a stepwise fashion duri ng T-cell differentiation has been revealed. One striking feature is t hat a single factor can act at several sites throughout T-cell develop ment, possibly through interactions with different partners. The chall enge is now to understand how these interactions can account for the c o-ordination of complex extracellular signals and gene expression prog rams, such as those involved in T-cell receptor gene recombination and expression. (C) Current Biology Ltd ISSN 0952-7915.