B-CELL RECEPTOR REGULATION OF PERIPHERAL B-CELLS

Authors
MACLENNAN ICM
Citation
Icm. Maclennan, B-CELL RECEPTOR REGULATION OF PERIPHERAL B-CELLS, Current opinion in immunology, 10(2), 1998, pp. 220-225
Citations number
50
Categorie Soggetti
Immunology
Journal title
Current opinion in immunology → ACNP
ISSN journal
09527915
Volume
10
Issue
2
Year of publication
1998
Pages
220 - 225
Database
ISI
SICI code
0952-7915(1998)10:2<220:BRROPB>2.0.ZU;2-#
Abstract
Recent studies indicate that immature B cells compete with recirculati ng B cells for survival signals. The signals, delivered through the B- cell receptor for antigen, induce immature cells to differentiate into recirculating cells and maintain the survival of recirculating cells. They do not induce proliferation or differentiation to antibody-produ cing cells. (C) Current Biology Ltd ISSN 0952-7915.