Background: Operative internal drainage has been standard treatment fo
r chronic unresolved pancreatic pseudocysts (PPs). Recently, percutane
ous external drainage (PED) has become the primary mode of treatment a
t many medical centers. Study Design: A retrospective chart review was
performed of 96 patients with PP's who were managed between 1987 and
1996. Longterm followup information was obtained by telephone anti mai
l questionnaire. Results: Twenty-seven patients underwent computed tom
ographic (CT)-guided PED. PP resolution occurred in 17 patients. Clini
cal deterioration or secondary infection mandated urgent pancreatic de
bridement in 7 (26%) patients and cystgastrostomy in 2 (7%) patients.
There was one hospital death in this group. Thirty-two patients underw
ent cystgastrostomy or cystjejunostomy (n = 21), distal pancreatectomy
(n = 8), pancreatic debridement and external drainage (n = 2), or cys
tectomy (n = 1). Two (6%) patients required postoperative pancreatic d
ebridement for failure of resolution and peritonitis and two patients
underwent PED of abscess. There was one hospital death in the expectan
tly managed group of 37 patients. Median followup of 3 years (range, 0
.5-9.3 years) in 66 patients revealed that 6, 3, and 4 patients of PED
, surgery, and expectantly managed groups, respectively, had radiologi
c evidence of recurrent PPs. Conclusions: Operative management for PPs
appears to be superior to CT-guided PED. Although the later was often
successful, it required major salvage procedures in one third of the
patients. An! expectant management protocol may be suitable for select
ed patients. (C) 1998 by the American College of Surgeons.