CHRONIC INFLAMMATORY DEMYELINATING POLYRADICULONEUROPATHY WITH DIFFUSE AND MASSIVE PERIPHERAL-NERVE HYPERTROPHY - DISTINCTIVE CLINICAL AND MAGNETIC-RESONANCE-IMAGING FEATURES
K. Mizuno et al., CHRONIC INFLAMMATORY DEMYELINATING POLYRADICULONEUROPATHY WITH DIFFUSE AND MASSIVE PERIPHERAL-NERVE HYPERTROPHY - DISTINCTIVE CLINICAL AND MAGNETIC-RESONANCE-IMAGING FEATURES, Muscle & nerve, 21(6), 1998, pp. 805-808
We present 3 patients with chronic inflammatory demyelinating polyradi
culoneuropathy (CIDP) with extensive and diffuse hypertrophy of the ne
rve roots and peripheral nerves. They exhibited slowly progressive sen
sory impairment and distally predominant limb weakness and muscular at
rophy, and markedly enlarged palpable nerve trunks. They responded ben
eficially to corticosteroid. Magnetic resonance imaging demonstrated d
iffuse and extensive hypertrophy of the peripheral nerves in the four
limbs and the spinal nerve roots, with gadolinium enhancement in the n
erve roots but not in the peripheral nerves. These patients were consi
dered to have a hypertrophic variant of CIDP. (C) 1998 John Wiley & So
ns, Inc.