ACTIVITIES OF HMR-3004 (RU-64004) AND HMR-3647 (RU-66647) COMPARED TOTHOSE OF ERYTHROMYCIN, AZITHROMYCIN, CLARITHROMYCIN, ROXITHROMYCIN, AND 8 OTHER ANTIMICROBIAL AGENTS AGAINST UNUSUAL AEROBIC AND ANAEROBIC HUMAN AND ANIMAL BITE PATHOGENS ISOLATED FROM SKIN AND SOFT-TISSUE INFECTIONS IN HUMANS

The activities of HMR 3004 and HMR 3647 and comparator agents, especia lly macrolides, were determined by the agar dilution method against 26 2 aerobic and 120 anaerobic strains isolated from skin and soft tissue infections associated with human and animal bite wounds. HMR 3004 and HMR 3647 were active against almost all aerobic and fastidious facult ative isolates (MIC at which 90% of the isolates are inhibited [MIC,,I , less than or equal to 0.5 and 1 mu g/ml, respectively) and against a ll anaerobes [Bacteroides tectum, Porphyromonas macacae (salivosa), Pr evotella heparinolytica, Porphyromonas sp,, Prevotella sp,, and peptos treptococci] at less than or equal to 0.25 and less than or equal to 0 .5 mu g/ml, respectively, except Fusobacterium nucleatum (HMR 3004, MI C90 = 16 mu g/ml; HMR 3647, MIC90= 8 mu g/ml) and other Fusobacterium species (MIC90, 1 and 2 mu g/ml, respectively). In general, HMR 3004 a nd HMR 3647 were more active than any of the macrolides tested. Azithr omycin was more active than clarithromycin against all Pasteurella spe cies, including Pasteurella multocida subsp. multocida, Eikenella corr odens, and Fusobacterium species, while clarithromycin was more active than azithromycin against Corynebacterium species,Weeksella zoohelcum , B, tectum, and P, heparinolytica.