CHARACTERIZATION OF GRLA, GRLB, GYRA, AND GYRB MUTATIONS IN 116 UNRELATED ISOLATES OF STAPHYLOCOCCUS-AUREUS AND EFFECTS OF MUTATIONS ON CIPROFLOXACIN MIC

Authors
SCHMITZ FJ JONES ME HOFMANN B HANSEN B SCHEURING S LUCKEFAHR M FLUIT A VERHOEF J HADDING U HEINZ HP KOHRER K
Citation
Fj. Schmitz et al., CHARACTERIZATION OF GRLA, GRLB, GYRA, AND GYRB MUTATIONS IN 116 UNRELATED ISOLATES OF STAPHYLOCOCCUS-AUREUS AND EFFECTS OF MUTATIONS ON CIPROFLOXACIN MIC, Antimicrobial agents and chemotherapy, 42(5), 1998, pp. 1249-1252
Citations number
20
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
42
Issue
5
Year of publication
1998
Pages
1249 - 1252
Database
ISI
SICI code
0066-4804(1998)42:5<1249:COGGGA>2.0.ZU;2-3
Abstract
One hundred sixteen unrelated clinical isolates of Staphylococcus aure us (70 ciprofloxacin resistant and 46 ciprofloxacin susceptible) from eight countries were studied for the presence of mutations in the grlA , grlB, gyrA, and gyrB gene loci. Two mutations within grlA (located a t codons 80 and 84) and two mutations within gyrA (located at codons 8 4 and 88) were clearly associated with ciprofloxacin resistance, altho ugh other mutations detected within the four genes studied may also co ntribute to decreased susceptibility.