COMPARATIVE ACTIVITIES OF CLINAFLOXACIN AGAINST GRAM-POSITIVE AND GRAM-NEGATIVE BACTERIA

Activities of clinafloxacin, ciprofloxacin, levofloxacin, sparfloxacin , trovafloxacin, piperacillin, piperacillin-tazobactam, trimethoprim-s ulfamethoxazole, ceftazidime, and imipenem against 354 ciprofloxacin-s usceptible and -intermediate-resistant organisms were tested by agar d ilution. Clinafloxacin yielded the lowest quinolone MICs (less than or equal to 0.5 mu g/ml against ciprofloxacin-susceptible organisms and less than or equal to 16.0 mu g/ml against ciprofloxacin-intermediate resistant organisms) compared to those of levofloxacin, trovafloxacin, and sparfloxacin. Ceftazidime, piperacillin alone or combined with ta zobactam, trimethoprim-sulfamethoxazole, and imipenem usually yielded higher MICs against ciprofloxacin-resistant strains.