ANTIBACTERIAL ACTIVITIES AND INHIBITORY EFFECTS OF SITAFLOXACIN (DU-6859A) AND ITS OPTICAL ISOMERS AGAINST TYPE-II TOPOISOMERASES

Authors
AKASAKA T KUROSAKA S UCHIDA Y TANAKA M SATO K HAYAKAWA I
Citation
T. Akasaka et al., ANTIBACTERIAL ACTIVITIES AND INHIBITORY EFFECTS OF SITAFLOXACIN (DU-6859A) AND ITS OPTICAL ISOMERS AGAINST TYPE-II TOPOISOMERASES, Antimicrobial agents and chemotherapy, 42(5), 1998, pp. 1284-1287
Citations number
31
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
42
Issue
5
Year of publication
1998
Pages
1284 - 1287
Database
ISI
SICI code
0066-4804(1998)42:5<1284:AAAIEO>2.0.ZU;2-0
Abstract
The in vitro inhibitory effects of sitafloxacin (DU-6859a) and its thr ee stereoisomers on bacterial DNA gyrase from Escherichia coli, topois omerase IV from Staphylococcus aureus and topoisomerase II from human placenta were compared. No correlation was observed between the inhibi tory activities of quinolones against bacterial type II topoisomerases and those against human topoisomerase II. Sitafloxacin showed the mos t potent inhibitory activities against bacterial type LI topoisomerase s and the lowest activity against human type II topoisomerase.