PROTECTION AGAINST LETHAL MURINE COCCIDIOIDOMYCOSIS BY A SOLUBLE VACCINE FROM SPHERULES

Authors
ZIMMERMANN CR JOHNSON SM MARTENS GW WHITE AG ZIMMER BL PAPPAGIANIS D
Citation
Cr. Zimmermann et al., PROTECTION AGAINST LETHAL MURINE COCCIDIOIDOMYCOSIS BY A SOLUBLE VACCINE FROM SPHERULES, Infection and immunity, 66(5), 1998, pp. 2342-2345
Citations number
37
Categorie Soggetti
Immunology,"Infectious Diseases
Journal title
Infection and immunity → ACNP
ISSN journal
00199567
Volume
66
Issue
5
Year of publication
1998
Pages
2342 - 2345
Database
ISI
SICI code
0019-9567(1998)66:5<2342:PALMCB>2.0.ZU;2-0
Abstract
The formaldehgde-killed, whole-spherule vaccine, which is protective a gainst lethal challenge of laboratory animals with Coccidioides immiti s, was fractionated. It yielded a soluble, multicomponent, subcellular fraction termed the 27K vaccine, This vaccine, when it was accompanie d by adjuvant, protected mice against lethal intranasal and intravenou s challenge with C. immitis.