INCLUSION AND RELEASE OF PROTEINS FROM POLYSACCHARIDE-BASED POLYION COMPLEXES

Citation
S. Dumitriu et E. Chornet, INCLUSION AND RELEASE OF PROTEINS FROM POLYSACCHARIDE-BASED POLYION COMPLEXES, Advanced drug delivery reviews, 31(3), 1998, pp. 223-246
Citations number
171
Categorie Soggetti
Pharmacology & Pharmacy
ISSN journal
0169409X
Volume
31
Issue
3
Year of publication
1998
Pages
223 - 246
Database
ISI
SICI code
0169-409X(1998)31:3<223:IAROPF>2.0.ZU;2-P
Abstract
The notion of a polyelectrolyte complex is well established for the co mplexation of two polymers one anionic, the other cationic. Electronic microscopy studies have shown the formation of a fibrilar structure. A method for the preparation of polyionic hydrogels from the complexat ion of chitosan and xanthan is reported. Electronic microscopy studies have shown the formation of a fibrilar structure. Stable hydrogels ha ve been used to immobilize xylanase: lipase and protease. The immobili zed xylanase and lipase activity was significantly higher than that of the free enzyme. (C) 1998 Elsevier Science B.V.