A NEW ROUTE TO ENE CARBAMATES, PRECURSORS TO BENZOINDOLIZINONES THROUGH SEQUENTIAL ASYMMETRIC HYDROGENATION AND CYCLIZATION

Authors
COUTURE A DENIAU E LEBRUN S GRANDCLAUDON P CARPENTIER JF
Citation
A. Couture et al., A NEW ROUTE TO ENE CARBAMATES, PRECURSORS TO BENZOINDOLIZINONES THROUGH SEQUENTIAL ASYMMETRIC HYDROGENATION AND CYCLIZATION, Journal of the Chemical Society. Perkin transactions. I, (8), 1998, pp. 1403-1407
Citations number
22
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of the Chemical Society. Perkin transactions. I → ACNP
ISSN journal
0300922X
Issue
8
Year of publication
1998
Pages
1403 - 1407
Database
ISI
SICI code
0300-922X(1998):8<1403:ANRTEC>2.0.ZU;2-R
Abstract
New pyrrolidine-based ene carbamates have been efficiently synthesized and the first example of asymmetric hydrogenation of this kind of sub strate is reported, leading to the preparation of 2-arylmethylpyrrolid ine precursors to benzoindolizinones in high yields and enantioselecti vities up to 57%.