THE USE OF HIGH-THROUGHPUT SYNTHESIS AND PURIFICATION IN THE PREPARATION OF A DIRECTED LIBRARY OF ADRENERGIC AGENTS

Authors
SIEGEL MG SHUKER AJ DROSTE CA HAHN PJ JESUDASON CD MCDONALD JH MATTHEWS DP RITO CJ THORPE AJ
Citation
Mg. Siegel et al., THE USE OF HIGH-THROUGHPUT SYNTHESIS AND PURIFICATION IN THE PREPARATION OF A DIRECTED LIBRARY OF ADRENERGIC AGENTS, Molecular diversity, 3(2), 1998, pp. 113-116
Citations number
17
Categorie Soggetti
Chemistry Applied","Chemistry Medicinal
Journal title
Molecular diversity → ACNP
ISSN journal
13811991
Volume
3
Issue
2
Year of publication
1998
Pages
113 - 116
Database
ISI
SICI code
1381-1991(1998)3:2<113:TUOHSA>2.0.ZU;2-I
Abstract
A library of potential agonists and antagonists for adrenergic recepto rs was prepared using high-throughput solution-phase parallel synthesi s. Traditional solution-phase reductive amination reactions followed b y rapid purification by ion exchange chromatography yielded products w ith near-analytical purity. An array of ketones and amines, arranged i n an 8 x 12 matrix, were combined to form 96 individual compounds.