SOLID-PHASE SYNTHESIS OF FUNCTIONALIZED BIARYL ETHERS - VERSATILE SCAFFOLDS FOR COMBINATORIAL CHEMISTRY

Authors
WIJKMANS JCHM CULSHAW AJ BAXTER AD
Citation
Jchm. Wijkmans et al., SOLID-PHASE SYNTHESIS OF FUNCTIONALIZED BIARYL ETHERS - VERSATILE SCAFFOLDS FOR COMBINATORIAL CHEMISTRY, Molecular diversity, 3(2), 1998, pp. 117-120
Citations number
22
Categorie Soggetti
Chemistry Applied","Chemistry Medicinal
Journal title
Molecular diversity → ACNP
ISSN journal
13811991
Volume
3
Issue
2
Year of publication
1998
Pages
117 - 120
Database
ISI
SICI code
1381-1991(1998)3:2<117:SSOFBE>2.0.ZU;2-W
Abstract
4-Fluoro-3-nitrobenzoic acid attached to a solid support was shown to react under mild conditions with a wide range of functionalized phenol s to yield, after cleavage, the corresponding biaryl ethers in excelle nt purity. In a similar fashion, biaryl thioethers could be obtained. Further elaboration of immobilized biaryl ethers demonstrates the pote ntial for combinatorial library generation.