4-Fluoro-3-nitrobenzoic acid attached to a solid support was shown to
react under mild conditions with a wide range of functionalized phenol
s to yield, after cleavage, the corresponding biaryl ethers in excelle
nt purity. In a similar fashion, biaryl thioethers could be obtained.
Further elaboration of immobilized biaryl ethers demonstrates the pote
ntial for combinatorial library generation.