SOLID-PHASE SYNTHESIS OF COMBINATORIAL LIBRARIES USING ANHYDRIDES AS TEMPLATES

A simple and general approach to the synthesis of chemical libraries b ased on a universal anhydride template allows the preparation of large number of compounds. Various cyclic/acyclic amines, primary/secondary amines, differentially protected bifunctional amines were used as nuc leophiles to react with anhydrides. The free carboxylic acid generated was then coupled with solid-bound amines. The facile and rapid genera tion of compounds through this multi-component assembly can be accompl ished in a combinatorial parallel synthesis.