RISK-FACTORS FOR INCREASED BONE LOSS IN AN ELDERLY POPULATION - THE ROTTERDAM STUDY

The association of bone loss with age, sex, and several prevalent and modifiable potential risk factors for osteoporosis was studied in 1,85 6 men and 2,452 women aged 55 years and over from the Rotterdam Study, a population-based cohort study in the Netherlands. The rate of chang e in femoral neck bone mineral density was estimated longitudinally be tween 1990 and 1995, after 2 years of follow-up on average, These rate s, adjusted for age and body mass index, were -0.0025 (95% confidence interval -0.0038 to -0.0012) in men and -0.0045 (95% confidence interv al -0.0056 to -0.0034) g/cm(2)/year in women (p = 0.03). Bone loss acc elerated with age, as seen more clearly in men than in women. Lower bo dy mass index and cigarette smoking were associated with increased ban e loss in both men and women. In men, higher calcium intake was associ ated with lower rates, and disability was associated with borderline s ignificantly higher rates of bone loss (p = 0.07), In women, a nonsign ificant relation was observed with disability, but not with dietary ca lcium intake. Alcohol intake was not consistently related to the rate of bone loss in either sex. It is concluded that in elderly people the rate of bone loss is higher in women? progresses with age, and is fur ther determined by several modifiable risk factors, particularly in me n.