DECONSTRUCTING GELSOLIN - IDENTIFYING SITES THAT MIMIC OR ALTER BINDING TO ACTIN AND PHOSPHOINOSITIDES

Gelsolin is involved in cytoskeletal remodeling as it can fragment and guide reassembly of actin networks. Recent advances in defining the s tructure of gelsolin identified functionally important sites. These st ructural insights could lead to the design of small molecule analogs t o enhance, inhibit or mimic the functions of gelsolin.