C. Zissis et al., THE EXTENT OF SURGERY AND PROGNOSIS OF PATIENTS WITH PHYLLODES TUMOR OF THE BREAST, Breast cancer research and treatment, 48(3), 1998, pp. 205-210
In an attempt to clarify the controversial issues related to prognosis
and therapeutic aspects of phyllodes tumors (PT), we retrospectively
reviewed all cases of PT treated in our hospital during the last fifte
en years. Re-examining the pathology material we found 84 cases, while
thirteen more cases which had been initially classified as fibroadeno
mas with areas of phyllodes tumor were rejected from the analysis beca
use they were classified as fibroadenomas. Based on the criteria propo
sed by Azzopardi and Salvadori and adopted by WHO, we found 55 benign
PT (65.14%), 14 borderline PT (16.6%), and 15 malignant PT (17.8%). Th
e median age of the patients with benign PT was 34 years, compared to
46.5 years for those with borderline tumors and 52 years for those wit
h malignant. The median size of benign tumors was 3 cm, 9.5 cm for bor
derline, and 7.25 cm for malignant. Out of 55 patients with benign PTs
, 37 underwent wide local excision and the remaining 18, with small tu
mors, underwent enucleation. In this group of patients, there was no r
ecurrence after a median interval of 6.65 years. Eleven patients with
borderline PT underwent wide local excision and three mastectomy; one
immediately after an incomplete PT excision and the remaining two 8 mo
nths and 2 years later due to a locally recurrent PT (the last one pro
ven histologically in the permanent biopsy of the recurrence to be mal
ignant). Twelve patients with malignant PT underwent mastectomy, eithe
r during the same operation or following the results of the permanent
section biopsy. Three more patients with malignant PT underwent wide l
ocal excision. The size of the tumor in these patients was relatively
small and the pathology report indicated clear margins with normal bre
ast tissue surrounding the tumor. One patient with 8 cm diameter malig
nant PT, who underwent mastectomy, passed away sixteen months later fr
om widely spread metastases. Applying the criteria of Azzopardi and Sa
lvadori, each case of PT can be managed successfully avoiding unnecess
ary mastectomies.