Extemporaneous compounding has long been a part of dermatology. It has
served to produce niche therapies that otherwise would have been poor
ly treated with available drugs. Increasingly however, the unpredictab
le nature of compounded medications, both in effectiveness, as well as
safety and stability of such products, has diminished the use of this
approach. The increasing availability of new pharmaceutical drugs tha
t fill these niches more effectively, coupled with economic and legal
concerns over the practice of compounding make it a tradition with an
increasingly limited role in dermatology today. It is safe to predict
that in the near future, compounding will virtually disappear from der
matology, as it already has from virtually all other medical specialti
es.