RAPID LIQUID-LIQUID-EXTRACTION OF COCAINE FROM URINE FOR GAS-CHROMATOGRAPHIC MASS-SPECTROMETRIC ANALYSIS

Authors
GARSIDE D GOLDBERGER BA PRESTON KL CONE EJ
Citation
D. Garside et al., RAPID LIQUID-LIQUID-EXTRACTION OF COCAINE FROM URINE FOR GAS-CHROMATOGRAPHIC MASS-SPECTROMETRIC ANALYSIS, Journal of chromatography B. Biomedical sciences and applications, 692(1), 1997, pp. 61-65
Citations number
25
Categorie Soggetti
Chemistry Analytical","Biochemical Research Methods
Journal title
Journal of chromatography B. Biomedical sciences and applications → ACNP
ISSN journal
13872273
Volume
692
Issue
1
Year of publication
1997
Pages
61 - 65
Database
ISI
SICI code
0378-4347(1997)692:1<61:RLOCFU>2.0.ZU;2-Q
Abstract
A novel, simple and economic liquid-liquid extraction method for isola ting cocaine from urine was developed utilizing gas chromatography-mas s spectrometry (CC-MS) for analysis and quantification. The use of a s ingle nonpolar organic solvent allowed only nonpolar analytes to be ex tracted from the biological fluid, and consequently, no derivatization step was necessary before CC-MS analysis. Large numbers of specimens (>60) can be extracted in approximately 3 h with this procedure. The m ethod is highly precise (C.V. <7%), accurate (>98%), sensitive (limit of detection of 5 ng/mI) and has a mean recovery of 48.8%.