The symmetries of the DNA double helix require a new term in its linea
r response to stress: the coupling between twist and stretch. Recent e
xperiments with torsionally constrained single molecules give the firs
t direct measurement of this new material parameter. We extract its va
lue from a recent experiment, Finally, we sketch the effect of constra
ined twist on entropic elasticity of DNA arising from the connection b
etween Link, Twist, and Writhe.