HIGH PREVALENCE OF THROMBOCYTOPENIA IN SLE PATIENTS WITH A HIGH-LEVELOF ANTICARDIOLIPIN ANTIBODIES COMBINED WITH LUPUS ANTICOAGULANT

The relationship between thrombocytopenia and the level of anticardiol ipin antibodies (aCL) and/or the existence of lupus anticoagulant (LA) ware studied in 146 patients with systemic lupus erythematosus (SLE). These patients were divided into six groups: A, those LA positive wit h a high level of aCL (>f 10 U/ml) (10 cases); B, those LA positive wi th a low level of aCL (3-10 U/ml) (15 cases); C, those LA positive but aCL negative (<3 U/ml) (12 cases); D, LA negatives with a high level of aCL (12 cases); E, LA negatives with a low level of aCL (16 cases); and F, aCL and LA double negatives (81 cases). The prevalence of thro mbocytopenia (platelet count less than or equal to 100 x 10(9)/L) was by far the highest in group A (9/10 cases, 90.0%, P < 0.005, Fisher's exact probability test) as compared with group B (4/15 cases, 26.7%), group C (4/12 cases, 33.3%), group D (1/12 cases, 8.3%), group E (4/16 cases, 25.5%), and group F (9/81 cases, 11.1%). When the relationship between moderate thrombocytopenia and arterial or venous thrombosis w as studied in these patients with SLE, thrombocytopenia was detected i n 10 (83.3%, P < 0.005, Fisher's exact probability test) of 12 patient s with arterial thrombosis; however, it was present in only 4 (23.5%) of 17 patients with venous thrombosis and in 14 (12.3%) of 114 patient s without thrombosis. These findings suggest that a high aCL activity combined with LA positively reflects a high risk for both thrombocytop enia and arterial thrombosis. (C) 1998 Wiley-Liss, Inc.