Contoured wounds needing closure with skin grafts are often located in
complex anatomic regions or are in unusual positions, which make conv
entional skin graft stabilization techniques cumbersome and ineffectiv
e. Often after 72 hours, a skin graft covered with a bolstered dressin
g has poor take secondary to shear stresses, as well as hematoma forma
tion or serum collection, negating the effectiveness of the stabilizin
g dressing. The Food and Drug Administration has recently approved vac
uum-assisted closure (V.A.C.), an innovative technique using negative
pressure, for closure of chronic wounds. This reportedly leads to enha
nced granulation tissue formation and consequently more rapid reepithe
lialization of wounds compared with conventional packing with saline-m
oistened gauze. Experimental studies have demonstrated increased oxyge
n tension, decreased bacterial counts, and increased granulation forma
tion occurring under negative-pressure systems. Extending the use of t
his concept, we have coupled skin grafting with negative-pressure dres
sings for closure of large, complex open wounds. Our results indicate
greater than 95% graft take in all patients in this study, This techni
que is extremely efficacious, with increased graft take due to total i
mmobilization of the graft, thereby limiting shear forces, elimination
of fluid collections, bridging of the graft, and decreased bacterial
contamination. Moreover we have noted decreased edema in rotated muscl
e flaps, improved contour conformity, and shortened hospitalizations.