PREGNANCY AND DIALYSIS

The outcome of pregnancy in patients with end-stage renal failure has long been considered to be extremely poor, and the literature concerni ng pregnancy while on dialysis is rather scarce. We reviewed the recor ds of five pregnancies in dialysis patients and performed a national s urvey on this topic. The dialysis technique and dialysis dose, the eff ects of erythropoietin (EPO), and the evolution of blood pressure leve ls in our patients are presented. The dose of EPO had to be increased to maintain the hemoglobin level at 10 to 11 g/dL. There was no case o f EPO-related hypertension and no need for transfusion. The obstetric data of the national survey, Including our own patients, were analyzed . The incidence of pregnancy going beyond the first trimester was 0.3 per 100 patient-years (15 cases in 1,472 females of childbearing age t reated, for a total of 4,545 patient-years). In all but one patient in itiating pregnancy while already on dialysis, the frequency and dose o f dialysis were increased (to a weekly Kt/V of six to eight in our per sonal cases). The outcome was successful in 50% of pregnancies occurri ng in hemodialyzed patients and in 80% of patients who started dialysi s after initiation of pregnancy. Polyhydramnios was found In eight of 13 cases and growth retardation in two of nine cases. The incidence of low birth weight and prematurity was 100%, and cesarean section was p erformed in 66% of successful pregnancies. In successful pregnancies, we found a correlation between birth weight and dose of dialysis, Our findings confirm the remarkable improvement in the prognosis of pregna ncy in dialysis patients in recent years. (C) 1998 by the National Kid ney Foundation, Inc.