PARANEOPLASTIC INTESTINAL PSEUDOOBSTRUCTI ON REVEALING SMALL-CELL LUNG-CARCINOMA - THE ANTI-HU SYNDROME

A 67-year-old woman was admitted for intestinal pseudo-obstruction ass ociated with peripheral sensitive neuropathy. Jejunal biopsies perform ed during laparotomy, showed axonal degeneration and lympho-plasmocyti c infiltration in myenteric plexus. High titer of seric anti-Hu antibo dies suggested a paraneoplastic syndrome. Thoracic CT scan showed medi astinal lymph nodes. Their histological examination confirmed the diag nosis of metastatic small-cell lung carcinoma. Her condition gradually deteriorated despite supportive parenteral nutrition, chemotherapy, s teroids and intravenous immunoglobulins. She died 12 months after the onset of symptoms.