J. Cossy et al., A SHORT ENANTIOSELECTIVE ACCESS TO PUMILIOTOXIN 251D FROM L-PROLINE, Bulletin de la Societe chimique de France, 134(2), 1997, pp. 141-144
The indolizidine framework of pumiliotoxin 251D with the appropriate f
unctionalities for incorporation of the tertiary hydroxyl at the C-8 a
nd the alkylidene side chain at C-6 has been accessed from L-proline b
y using a 6-exo-dig radical cyclization.