EXCLUSION OF GENETIC-LINKAGE TO 4Q21-23 AND 17Q21 IN A FAMILY WITH LEWY BODY PARKINSONISM

Genetic analysis of markers from chromosomes 4q21-23 and 17q21 in a fa mily with apparently autosomal dominant Lewy body parkinsonism is pres ented. This analysis shows that the locus leading to this disease is n ot allelic with that previously shown to lead to Lewy body parkinsonis m on chromosome 4 or to the locus on chromosome 17 leading to frontote mporal dementia with parkinsonism. A brief clinical comparison of this family with families showing linkage to these loci is presented. The data suggest that at least one other major genetic determinant for Lew y body parkinsonism remains to be identified. (C) 1998 Wiley-Liss, Inc .