CHANGES IN REPRESENTATION OF TRANSFORMING -GROWTH-FACTOR-ALPHA MOLECULAR-FORMS AND EGF RECEPTOR MESSENGER-RNA IN NDEA-INDUCED HEPATOCARCINOGENESIS IN RATS

Authors
GARMANCHOUK LV HOBTA AI MARKEYEVA NV POGREBNOY PV BYKOREZ AI
Citation
Lv. Garmanchouk et al., CHANGES IN REPRESENTATION OF TRANSFORMING -GROWTH-FACTOR-ALPHA MOLECULAR-FORMS AND EGF RECEPTOR MESSENGER-RNA IN NDEA-INDUCED HEPATOCARCINOGENESIS IN RATS, Eksperimental'naa onkologia, 20(1), 1998, pp. 29-32
Citations number
17
Categorie Soggetti
Oncology
Journal title
Eksperimental'naa onkologia → ACNP
ISSN journal
02043564
Volume
20
Issue
1
Year of publication
1998
Pages
29 - 32
Database
ISI
SICI code
0204-3564(1998)20:1<29:CIROT->2.0.ZU;2-M
Abstract
DENA-induced changes in the expression pattern of transforming growth factor alpha and EGF receptor on the different stages of hepatocarcino genesis in rats were investigated. As a result, an enhanced synthesis of different molecular forms of TGF-alpha during the tumor progression has been shown. During hepatocarcinogenesis disorders in representati on of EGFR encoding mRNA have been detected. The expression of 5.8 kb mRNA was enhanced significantly, and in contrast to that, 10.2 kb frag ment, that is characteristic of liver tissue at the early stages of ca rcinogenesis disappears in tumors.