EXPRESSION OF ACTIVATION AND PROLIFERATIO N MARKERS IN MH-RHABDOMYOSARCOMA AND MELANOMA B-16 CELLS INDUCED BY SOME IMMUNOMODULATORS

The effect of different immunomodulators (thymalin, laferon, interleuk in-2 (IL-2), decaris) on the expression of activation (IL-2 receptor a nd transferrin receptor) and proliferation (IPO-38 antibody-recognized nuclear protein) markers in tumor cells (Mh-rhabdomyosarcoma of mice BALB/c and melanoma B-16 of mice C57BI/6) was studied. Method of indir ect fluorescent microscopy and monoclonal antibodies against these mar kers was used. Data showed that indicated immunomodulators influence i n a different way the expression of the activation and proliferation m arkers in tumor cells of different origin. The expression of activatio n and proliferation markers in tumor cells is a process that depends o n the mechanisms of action of immunomodulators and properties of tumor cells. Possible ways and conditions of realization of the effects of indicated immunomodulators on different tumor cells are discussed.