Ss. Lentz et al., EFFECTS OF PERIOPERATIVE BLOOD-TRANSFUSION ON PROGNOSIS IN EARLY-STAGE CERVICAL-CANCER, Annals of surgical oncology, 5(3), 1998, pp. 216-219
Background: This study was designed to evaluate the prognostic effects
of transfusion on patients undergoing radical hysterectomy for early
cervical cancer.Methods: This retrospective chart review analyzed 413
patients with stage IA-IIA disease, of whom 374 were evaluable. Result
s: Three hundred (80%) patients received transfusions and 74 (20%) did
not. The clinical characteristics of the two groups were similar, wit
h the exception that the transfused group was older. Pathologic compar
isons found that microscopic parametrial disease and larger cervical l
esions were more common in the transfused group. Follow-up analysis re
vealed no difference between the two groups in recurrence or survival.
Multivariate analysis found only grade, depth of invasion, and nodal
status as independent predictors of recurrence and survival. Kaplan-Me
ier survival analysis showed no difference in overall survival or dise
ase-free interval between the transfused and non-transfused groups. Co
nclusions: After correction for other prognostic factors, blood transf
usion had no prognostic significance in patients with early cervical c
ancer undergoing radical hysterectomy.