EFFECTS OF PERIOPERATIVE BLOOD-TRANSFUSION ON PROGNOSIS IN EARLY-STAGE CERVICAL-CANCER

Background: This study was designed to evaluate the prognostic effects of transfusion on patients undergoing radical hysterectomy for early cervical cancer.Methods: This retrospective chart review analyzed 413 patients with stage IA-IIA disease, of whom 374 were evaluable. Result s: Three hundred (80%) patients received transfusions and 74 (20%) did not. The clinical characteristics of the two groups were similar, wit h the exception that the transfused group was older. Pathologic compar isons found that microscopic parametrial disease and larger cervical l esions were more common in the transfused group. Follow-up analysis re vealed no difference between the two groups in recurrence or survival. Multivariate analysis found only grade, depth of invasion, and nodal status as independent predictors of recurrence and survival. Kaplan-Me ier survival analysis showed no difference in overall survival or dise ase-free interval between the transfused and non-transfused groups. Co nclusions: After correction for other prognostic factors, blood transf usion had no prognostic significance in patients with early cervical c ancer undergoing radical hysterectomy.