We report on two patients with granulomatous rosacea and another patie
nt with granulomatous perioral dermatitis who responded well to dapson
e. Dapsone has a pharmacological double function as both an antibiotic
and an antiphlogistic drug. Before the introduction of isotretinoin,d
apsone had its place in the treatment of severe acne. To date, its use
in granulomatous rosacea has not been described. When hematologic par
ameters are monitored, dapsone is considered a safe and cost-effective
drug, especially in countries where isotretinoin is not readily avail
able. However, the definite value of dapsone in granulomatous rosacea
should be established by a controlled study.