SYNTHESES OF -4-(4-HALOPHENYL)-2,3-DIHYDRO-1,5-BENZOTHIAZEPINES

The reactions of 5-substituted-2-aminobenzenethiols with beta-(4-chlor obenzoyl)- and beta-(4-bromobenzoyl)acrylic acids have been carried ou t in methanol containing traces of glacial acetic acid to yield in a s ingle step, 8-substituted-2-carboxy-4-(4-chlorophenyl and 4-bromopheny l)-2,3-dihydro-1,5-benzothiazepines, the substituents being C1, Br as halogen; CH3 as alkyl, and OCH3 and OC2H5 as alkoxyl. The structural a ssignments have been made by a study of microanalyses of the elements and IR, H-1 NMR and mass spectral studies of the title compounds.