CHEMOENZYMATIC TRANSFORMATIONS IN SENSITIVE SYSTEMS - LIPASE-MEDIATEDHYDROLYSIS OF VANCOMYCIN ESTERS

Recently, an interest in the development of new vancomycin derivatives has been demonstrated. Here, the feasibility of using lipases, partic ularly those from Pseudomonas sp., for the hydrolysis of vancomycin al kyl esters is demonstrated. Benzyl ester derivatives were more easily cleavable than methyl ester derivatives, resulting in good yields of v ancomycin acids without degradation. (C) 1998 Elsevier Science Ltd. Al l rights reserved.