PEPTIDYL HUMAN HEART CHYMASE INHIBITORS - 1 - SYNTHESIS AND INHIBITORY ACTIVITY OF DIFLUOROMETHYLENE KETONE DERIVATIVES BEARING P'-BINDING SUBSITES

Authors
EDA M ASHIMORI A AKAHOSHI F YOSHIMURA T INOUE Y FUKAYA C NAKAJIMA M FUKUYAMA H IMADA T NAKAMURA N
Citation
M. Eda et al., PEPTIDYL HUMAN HEART CHYMASE INHIBITORS - 1 - SYNTHESIS AND INHIBITORY ACTIVITY OF DIFLUOROMETHYLENE KETONE DERIVATIVES BEARING P'-BINDING SUBSITES, Bioorganic & medicinal chemistry letters, 8(8), 1998, pp. 913-918
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
8
Year of publication
1998
Pages
913 - 918
Database
ISI
SICI code
0960-894X(1998)8:8<913:PHHCI->2.0.ZU;2-D
Abstract
Peptidyl difluoromethylene ketone derivatives were designed to take ad vantage of probable additional interactions with the S' subsite of hum an heart chymase. They showed potent inhibitory activities against hum an heart chymase and were more efficient than bovine chymotrypsin. (C) 1998 Elsevier Science Ltd. All rights reserved.