SYNTHESIS AND METABOTROPIC GLUTAMATE-RECEPTOR ACTIVITY OF A 2-AMINOBICYCLO[3.2.0]HEPTANE-2,5-DICARBOXYLIC ACID, A MOLECULE POSSESSING AN EXTENDED GLUTAMATE CONFORMATION

Authors
KOZIKOWSKI AP ARALDI GL FLIPPENANDERSON J GEORGE C PSHENICHKIN S SURINA E WROBLEWSKI J
Citation
Ap. Kozikowski et al., SYNTHESIS AND METABOTROPIC GLUTAMATE-RECEPTOR ACTIVITY OF A 2-AMINOBICYCLO[3.2.0]HEPTANE-2,5-DICARBOXYLIC ACID, A MOLECULE POSSESSING AN EXTENDED GLUTAMATE CONFORMATION, Bioorganic & medicinal chemistry letters, 8(8), 1998, pp. 925-930
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
8
Year of publication
1998
Pages
925 - 930
Database
ISI
SICI code
0960-894X(1998)8:8<925:SAMGAO>2.0.ZU;2-G
Abstract
A photochemical approach to the synthesis of the aminobicycloheptane 6 a is reported. This compound assumes an extended glutamate conformatio n, and for this reason was created to further probe the structural fea tures relevant to achieving selectivity for the subtypes of the metabo tropic glutamate family of receptors. (C) 1998 Elsevier Science Ltd. A ll rights reserved.