DNA COPY NUMBER AMPLIFICATIONS IN HUMAN NEOPLASMS - REVIEW OF COMPARATIVE GENOMIC HYBRIDIZATION STUDIES

This review summarizes reports of recurrent DNA sequence copy number a mplifications in human neoplasms detected by comparative genomic hybri dization, Some of the chromosomal areas with recurrent DNA copy number amplifications (amplicons) of 1p22-p31, 1p32-p36, 1q, 2p13-p16, 2p23- p25, 2q31-q33, 3q, 5p, 6p12-pter, 7p12-p13, 7q11.2, 7q21-q22, 8p11-p12 , 8q, 11q13-q14, 12p, 12q13-q21, 13q14, 13q22-qter, 14q13-q21, 15q24-q ter, 17p11.2-p12, 17q12-q21, 17q22-qter, 18q, 19p13.2-pter, 19cenq13.3 , 20p11.2-p12, 20q, Xp11.2-p21, and Xp11-q13 and genes therein are pre sented in more detail. The paper with more than 150 references and two tables can be accessed from our web site http://www.helsinki.fi/simil ar to-lgl_www/CMG.html. The data will be updated biannually until the year 2001.