U. Selditz et al., DIRECT ENANTIOMERIC SEPARATION OF MIANSERIN AND 6-AZAMIANSERIN DERIVATIVES USING CHIRAL STATIONARY PHASES, Journal of chromatography, 803(1-2), 1998, pp. 169-177
Citations number
33
Categorie Soggetti
Chemistry Analytical","Biochemical Research Methods
The direct enantiomeric separation of mianserin and 6-azamianserin and
some of their derivatives, respectively, by means of HPLC using two d
ifferent chiral selectors was investigated. For the cellulose-based Ch
iralcel OD column, a strong dependence of be lipophilicity of the comp
ounds tested on the retention behaviour was observed. To some extent,
this was also found for the enantiomeric separation on the amylose-bas
ed Chiralpak AD column. In some cases a complementary behaviour of the
se two phases was observed: racemic mixtures that could not be separat
ed by one column could be resolved by the other one. (C) 1998 Elsevier
Science Ltd.