DIRECT ENANTIOMERIC SEPARATION OF MIANSERIN AND 6-AZAMIANSERIN DERIVATIVES USING CHIRAL STATIONARY PHASES

The direct enantiomeric separation of mianserin and 6-azamianserin and some of their derivatives, respectively, by means of HPLC using two d ifferent chiral selectors was investigated. For the cellulose-based Ch iralcel OD column, a strong dependence of be lipophilicity of the comp ounds tested on the retention behaviour was observed. To some extent, this was also found for the enantiomeric separation on the amylose-bas ed Chiralpak AD column. In some cases a complementary behaviour of the se two phases was observed: racemic mixtures that could not be separat ed by one column could be resolved by the other one. (C) 1998 Elsevier Science Ltd.