EVALUATION OF NEEDLE-BIOPSY IN THE DIAGNOSIS OF PROSTATIC-CARCINOMA IN MEN WITH PROSTATIC INTRAEPITHELIAL NEOPLASIA

Prostatic intraepithelial neoplasia (PIN) is considered a premalignant lesion of the prostate. It is often encountered in prostate needle bi opsy in cases where no cancer is identified. In order to evaluate its importance 25 patients with PIN in a former prostate needle biopsy und erwent a second ultrasound guided needle biopsy. The first biopsy was performed in all patients as a result of positive DRE. In 13 patients (52%), prostate cancer was identified in the second specimen. All pres ented with high or intermediate grade PIN in the first biopsy. PSA val ues were compared with PIN grade and cancer presentation in the second biopsy, although no statistically significant difference was proven. In conclusion, when PIN is discovered in prostate needle biopsy in pat ients with positive DRE, a second biopsy has to be performed in order to exclude the possibility of a prostate carcinoma.