[F-18] FDG SYNTHESIS BY ANATECH RB-86 ROBOTIC SYSTEM - IMPROVEMENTS AND GENERAL-CONSIDERATIONS

A series of changes and updatings to the [F-18]FDG setup of the Anatec h RE-86 robotic system are described. They include improved [O-18]H2O recovery, ''one-pot'' reaction, elimination of the SPE step and base-a ssisted hydrolysis. Considerations on this last point are also reporte d. Thus, a remarkable improvement in the radiochemical yield, which is now 81% (decay corrected to SOS) with a synthesis time of just 40 min utes, has been achieved. The influence of several different reaction v essel materials on the synthesis is also briefly examined.