LIPOPROTEIN PROFILE IN CANINE PANCREATITIS INDUCED WITH OLEIC-ACID

Lipid and lipoprotein concentrations and apolipoprotein profile were i nvestigated in canine pancreatitis induced by infusion with oleic acid (OA) into the accessory pancreatic duct. Pancreatitis was diagnosed b y physical, hematological, biochemical and pathological examinations. In Oh-treated dogs, serum triglyceride (TG) concentration was increase d; however, there were no changes in serum total cholesterol (TC) and phospholipid (PL) concentrations. Serum concentrations of TG, TC, PL a nd total lipids (TL) in beta lipoprotein and those of TC, PL and TL in pre-beta lipoprotein were increased and those of TC, PL and TL in alp ha. lipoprotein were decreased. In apolipoprotein profile, the proport ions of apolipoprotein B100 in low density lipoprotein fraction and ap olipoprotein A-IV in high density lipoprotein fraction were increased. In addition, decreased proportion. of apolipoprotein A-I and the appe arance of serum amyloid A protein in high density lipoprotein fraction were observed. These results suggest that lipoprotein profiles observ ed in canine acute pancreatitis are attributed to the alterations in a polipoprotein compositions.