SYNTHESIS OF A SERIES OF HEXITOL AND AMINODEOXYHEXITOL MONONITRATE DERIVATIVES CONTAINING A SULFUR GROUP AND PHARMACOLOGICAL EVALUATION ON ISOLATED RAT AORTAS

As part of our research into new organic nitrates for the treatment of angina pectoris, we have investigated a series of hexitol and aminode oxyhexitol mononitrate derivatives containing a sulfur group. Since th e depletion of tissue stores of sulfhydryl groups appears to play an i mportant role in the development of this phenomenon, the addition of a sulfur group to a nitrate derivative could prevent the development of nitrate tolerance during a long-term treatment. Before studying the d uration of action, and the possible influence on tolerance phenomenon, it was important to check the vasorelaxing effects of our compounds c ompared to those of commercial organic nitrates of similar structures such as isosorbide mononitrate or isosorbide dinitrate. All the compou nds were tested on isolated rat aortas; some of these products exhibit ed an interesting activity.