COMPARISON OF IN-VITRO ACTIVITY OF TROVAFLOXACIN AGAINST GRAM-POSITIVE AND GRAM-NEGATIVE ORGANISMS WITH QUINOLONES AND BETA-LACTAM ANTIMICROBIAL AGENTS
Lm. Dembry et al., COMPARISON OF IN-VITRO ACTIVITY OF TROVAFLOXACIN AGAINST GRAM-POSITIVE AND GRAM-NEGATIVE ORGANISMS WITH QUINOLONES AND BETA-LACTAM ANTIMICROBIAL AGENTS, Diagnostic microbiology and infectious disease, 31(1), 1998, pp. 301-311
The in vitro activity of trovafloxacin against 721 Gram-negative and 4
98 Gram-positive organisms was determined by the standard microdilutio
n broth method using commercially prepared frozen microtiter plates. T
he activity of trovafloxacin was compared to ofloxacin, ciprofloxacin,
amoxicillin/clavulanate, ampicillin/sulbactam (1:1), piperacillin/taz
obactam, ceftriaxone, and imipenem. Trovafloxacin had equal or greater
activity compared with the other agents tested against Citrobacter di
versus, Enterobacter aerogenes, Enterobacter cloacae, Escherichia coli
, Haemophilus influenzae, Stenotrophomonas maltophilia, Serratia marce
scens, staphylococci, Streptococcus pneumoniae, Streptococcus pyogenes
, Streptococcus viridans, group G streptococci, Enterococcus faecalis,
and E. faecium. The reliability of the commercially prepared plates f
or testing the in vitro activity of the quinolones was evaluated by co
mparing identical isolates also tested by broth microdilution using la
boratory prepared plates. The commercially prepared plates generally c
orrelated, within one- to twofold dilutions, with the laboratory prepa
red plates. There was, however, a large discrepancy obtained when test
ing Enterobacter agglomerans and E. cloacae, where the commercially pr
epared plates yielded a significantly higher MIC90 value. (C) 1998 Els
evier Science Inc.