COMPARISON OF IN-VITRO ACTIVITY OF TROVAFLOXACIN AGAINST GRAM-POSITIVE AND GRAM-NEGATIVE ORGANISMS WITH QUINOLONES AND BETA-LACTAM ANTIMICROBIAL AGENTS

Citation
Lm. Dembry et al., COMPARISON OF IN-VITRO ACTIVITY OF TROVAFLOXACIN AGAINST GRAM-POSITIVE AND GRAM-NEGATIVE ORGANISMS WITH QUINOLONES AND BETA-LACTAM ANTIMICROBIAL AGENTS, Diagnostic microbiology and infectious disease, 31(1), 1998, pp. 301-311
Citations number
10
Categorie Soggetti
Microbiology,"Infectious Diseases
ISSN journal
07328893
Volume
31
Issue
1
Year of publication
1998
Pages
301 - 311
Database
ISI
SICI code
0732-8893(1998)31:1<301:COIAOT>2.0.ZU;2-O
Abstract
The in vitro activity of trovafloxacin against 721 Gram-negative and 4 98 Gram-positive organisms was determined by the standard microdilutio n broth method using commercially prepared frozen microtiter plates. T he activity of trovafloxacin was compared to ofloxacin, ciprofloxacin, amoxicillin/clavulanate, ampicillin/sulbactam (1:1), piperacillin/taz obactam, ceftriaxone, and imipenem. Trovafloxacin had equal or greater activity compared with the other agents tested against Citrobacter di versus, Enterobacter aerogenes, Enterobacter cloacae, Escherichia coli , Haemophilus influenzae, Stenotrophomonas maltophilia, Serratia marce scens, staphylococci, Streptococcus pneumoniae, Streptococcus pyogenes , Streptococcus viridans, group G streptococci, Enterococcus faecalis, and E. faecium. The reliability of the commercially prepared plates f or testing the in vitro activity of the quinolones was evaluated by co mparing identical isolates also tested by broth microdilution using la boratory prepared plates. The commercially prepared plates generally c orrelated, within one- to twofold dilutions, with the laboratory prepa red plates. There was, however, a large discrepancy obtained when test ing Enterobacter agglomerans and E. cloacae, where the commercially pr epared plates yielded a significantly higher MIC90 value. (C) 1998 Els evier Science Inc.