The divalent cations, calcium and magnesium, play a vital role in neur
omuscular function and cellular metabolism. Hypocalcemia related to pa
rathyroid disorder, renal failure, puerperal tetany, and various toxic
ities is well documented in veterinary medicine. The recent availabili
ty of ionized calcium measurement is helping to increase the accuracy
of detection of this state. Recent evidence suggests that hypomagnesem
ia is also a significant presence, particularly in critically ill pati
ents, with clinical significance relating mainly to concomitant electr
olyte deficiencies, such as hypokalemia.