THE L7 L12 RIBOSOMAL DOMAIN OF THE RIBOSOME - STRUCTURAL AND FUNCTIONAL-STUDIES/

The L7/L12 protein forms a functionally important domain in the riboso me. This domain is involved in interaction with translation factors du ring protein biosynthesis. The tertiary and quaternary structure of th e L7/L12 protein was established as a result of intensive studies in s olution and in the ribosome. The conformational changes of L7/L12, the elongation factors To and G and other ribosomal proteins were traced by different experimental techniques. These changes occur upon interac tion of the ribosome with the elongation factors and depend on GTP hyd rolysis in accordance with the functional states of the ribosome. (C) 1997 Federation of European Biochemical Societies.