LONG-TERM EFFECT OF A SINGLE-DOSE OF FLUNARIZINE IN HUNTINGTONS-DISEASE

Authors
BELFIORE G DIMAIO L NAPOLITANO G CELLA S FILLA A DEMICHELE G CAMPANELLA G
Citation
G. Belfiore et al., LONG-TERM EFFECT OF A SINGLE-DOSE OF FLUNARIZINE IN HUNTINGTONS-DISEASE, European journal of neurology, 5(3), 1998, pp. 249-253
Citations number
18
Categorie Soggetti
Neurosciences,"Clinical Neurology
Journal title
European journal of neurology → ACNP
ISSN journal
13515101
Volume
5
Issue
3
Year of publication
1998
Pages
249 - 253
Database
ISI
SICI code
1351-5101(1998)5:3<249:LEOASO>2.0.ZU;2-Z
Abstract
We report a preliminary pilot study on the clinical efficacy of flunar izine (FNZ), a calcium-entry blocker that causes extrapyramidal side-e ffects, in 10 patients with Huntington's disease (HD). FNZ (20 mg) adm inistered by the sublingual route resulted in a decrease in choreic mo vements and improved dexterity in performing several tests. These effe cts lasted for at least 7 days after a single dose. Therefore, FNZ see ms to exert the same effect as a long-acting neuroleptic agent in our HD patients. (C) 1998 Lippincott-Raven Publishers.