FATAL OBSTRUCTIVE LUNG-DISEASE AFTER HAPLOIDENTICAL SIBLING CORD-BLOOD TRANSPLANTATION

We report the case of a patient with fatal obstructive lung disease af ter an HLA-haploidentical sibling cord blood transplant (CBT), with se vere acute GVHD. A 2-year-old girl developed expiratory air trapping g radually with acute and chronic GVHD after CBT for the treatment of AL L. Anti-CMV and immunosuppressive therapy were ineffective, and the pa tient died of progressive respiratory acidosis. Necropsy of the lung r evealed severe bronchiolitis obliterans with cytomegalic inclusion cel ls in the granulation tissues of the bronchiolitis. Thus, immunologic and GVHD problems can occur even in CBT.