ACHIEVEMENT OF COMPLETE CYTOGENETIC REMISSION AFTER 2 VERY LOW-DOSE DONOR LEUKOCYTE INFUSIONS IN A PATIENT WITH EXTENSIVE CGVHD RELAPSING IN ACCELERATED PHASE POST ALLOGENEIC BMT FOR CML

We report the case of a 55-year-old female who despite having develope d extensive chronic graft-versus-host disease (GVHD), relapsed 35 mont hs after a T cell-replete sibling donor bone marrow transplant for Phi ladelphia-positive chronic myeloid leukaemia (Ph CML), She achieved co mplete cytogenetic remission after discontinuation of cyclosporin A an d administration of two low-dose donor leucocyte infusions (DLI 1x10(6 ) and 5x10(6) CD3(+) cells/kg). Eighteen months after the first infusi on she remains well and in complete cytogenetic remission with a normo cellular marrow and no exacerbation of GVHD.