M. Shaw et al., PACLITAXEL, BROPIRIMINE AND LINOMIDE - EFFECT ON GROWTH-INHIBITION INA MURINE PROSTATE-CANCER MODEL BY DIFFERENT GROWTH-REGULATORY MECHANISMS, Methods and findings in experimental and clinical pharmacology, 20(2), 1998, pp. 111-114
Paclitaxel, bropirimine and linomide therapy was evaluated in a murine
prostate cancer model. All drugs were effective in impeding tumor gro
wth but the mechanisms of action varied. Paclitaxel inhibited bcl-2 ex
pression suggesting an apoptotic mechanism. Bropirimine, while inhibit
ing bcl-2 expression also significantly depressed tumor necrosis facto
r-alpha (TNF-alpha) expression. In the bropirimine treated group there
was also a correlation between angiogenesis and cyclin D expression.
Finally, linomide significantly decreased angiogenesis. Since the mech
anism of action of these drugs differ, combining them at lower doses m
ight maintain therapeutic efficacy while reducing toxicity. (C) 1998 P
rous Science. All right reserved.