LOSARTAN IN CUSHINGS-SYNDROME

Authors
ZACHARIEVA S ORBETZOVA M NATCHEV E VERGILOVA J ANDREWA M WIPPERRNANN M TORBOVA S TZINGILEV D ANGELOVAGATEVA P
Citation
S. Zacharieva et al., LOSARTAN IN CUSHINGS-SYNDROME, Methods and findings in experimental and clinical pharmacology, 20(2), 1998, pp. 163-168
Citations number
35
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Methods and findings in experimental and clinical pharmacology → ACNP
ISSN journal
03790355
Volume
20
Issue
2
Year of publication
1998
Pages
163 - 168
Database
ISI
SICI code
0379-0355(1998)20:2<163:>2.0.ZU;2-J
Abstract
Eleven patients with Cushing's syndrome were included in the study. Th ey maintained their usual sodium uptake and received a single oral dos e of 50 mg of the angiotensin II antagonist receptor losartan for 3 da ys. Losartan treatment resulted in stimulation of active renin and dec rease of plasma and urinary kallikrein activity. Both systolic and dia stolic blood pressure decreased independently of baseline level of act ive renin. The relationship between kallikrein and renin-angiotensin s ystem are discussed. (C) 1998 Prous Science. All rights reserved.